The shelf life of Cialis tablets is 3 years from the date of release. They must be stored in a dark, dry place out of the reach of children and in undamaged original packaging at an air temperature not exceeding + 30 ° C.

Increased concentrations of cGMP are also observed in the smooth muscles of the bladder, prostate and blood vessels supplying them.

  • Relaxation of the vascular musculature contributes to an increase in blood perfusion (passage) in these organs and a decrease in the severity of BPH symptoms, and relaxation of the smooth muscles of the bladder and prostate further enhances the vascular effects.
  • By improving erection, tadalafil thus increases the possibility of PA (sexual intercourse).
  • At the same time, in healthy men, in comparison with placebo, it does not cause a significant change in the change in DBP, SBP and heart rate, does not affect the electroretinogram, visual acuity, IOP and pupil size, does not impair the ability to recognize colors (green / blue).
  • After taking the tablet, tadalafil is well absorbed in the body.
  • The concentration of the substance in the blood plasma reaches its peak values ​​2 hours after ingestion. Food and the time of taking the drug do not have a clinically significant effect on the rate of absorption of tadalafil and its bioavailability.

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About 94% of the substance is associated with plasma proteins. It is metabolized in the liver with the participation of the isoenzyme CYP3A4. The main circulating metabolite, in comparison with tadalafil, exhibits at least 13 thousand times less activity in relation to PDE-5.

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  • The drug is used for ED (erectile dysfunction); with LUTS (lower urinary tract symptoms) in patients with BPH; for ED in patients with LUTS associated with BPH.
  • This hypersensitivity to tadalafil or ancillary components of tablets; the simultaneous use of any preparation containing organic nitrates; concomitant use of Doxazosin or drugs for the treatment of ED.
  • CHF II-IV classes according to the NYHA classification, hypertension, uncontrolled arrhythmias, transferred during the last six months ischemic stroke ); associated or not associated with the use of PDE-5 inhibitors NAION (anterior ischemic neuropathy of the optic nerve); lactose intolerance, lactase deficiency, glucose / galactose malabsorption.